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David J. Margolis, MD,PhD

Arch Dermatol. 2002;138:1597-1598.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Commentary on: Pentoxifylline for the treatment of venous leg ulcers: a systematic review
Jull A, Waters J, Arroll B
Lancet. 2002;359:1550-1554

Question: What is the effect of pentoxifylline on the healing of venous leg ulcer?

Data Sources: The CENTRAL registers of the Cochrane Wounds Group and the Cochrane Peripheral Vascular Diseases Group. The authors also contacted Aventis Pharma France to obtain unpublished studies.

Studies: Studies were selected for inclusion if they were randomized clinical trials and reported either the percentage of change in ulcer area, percentage of ulcers healed, or percentage ulcer improvement of the patients' primary reference ulcer. Studies of all languages were included for analysis.

Data Synthesis: Cochrane software RevMan 4.1 (Cochrane Collaboration, Oxford, England) was used to estimate relative risks and 95% confidence intervals. The meta-estimates were also evaluated for study-based heterogeneity and for publication bias.

Results: The authors found 8 trials. . . . [Full Text of this Article]

Comment

Departments of Dermatology and Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia

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