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In the February issue of the ARCHIVES, Cerroni et al¹ compared 16 patients with follicular mucinosis (FM) occurring without mycosis fungoides (MF) with 28 patients with FM occurring in the setting of MF. These authors found that there was a considerable overlap in the histological features, molecular analyses, and clinical presentation between these 2 presentations of FM, and they concluded that idiopathic FM may represent a variant of localized MF. In an accompanying editorial, Sangüeza and Lu² praised this work and appeared to agree with the conclusion that many FM are low-grade cutaneous T-cell lymphomas from the onset. In my opinion, analysis of the authors' reported data on outcomes for their 44 patients suggest a different conclusion, namely, that idiopathic FM and FM associated with MF are distinct diseases with different outcomes.

In fact, the results presented by Cerroni et al¹ demonstrate that they were able to effectively divide their . . . [Full Text of this Article]

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