Mycophenolate Mofetil for the Treatment of Cutaneous Lupus Erythematosus With Smoldering Systemic Involvement
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Mycophenolate mofetil has been successfully used for the treatment of several autoimmune and inflammatory skin diseases.1 Although multiple studies support the use of mycophenolate mofetil in systemic lupus erythematosus (LE), only 3 cases describing its use in chronic cutaneous LE without systemic involvement have been reported.2-3 We discuss the role of mycophenolate mofetil in the management of multiple variants of cutaneous LE with associated systemic disease (Table 1).
Table appears in full text version.
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Clinical Features of Patients With Cutaneous Lupus Erythematosus (LE) Treated With Mycophenolate Mofetil*
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Index Case
A 58-year-old black woman with a 17-year history of systemic and discoid LE presented with an 18-month history of generalized lupus profundus and a new systemic flare. She was treated with prednisone (0.75 mg/kg per day), which was tapered over a period of 9 months after development of diabetes mellitus and hypertension. A combination treatment of hydroxychloroquine sulfate (6 mg/kg per day), quinacrine hydrochloride (3 mg/kg per . . . [Full Text of this Article]
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