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Tazarotene Is an Effective Therapy for Elastosis Perforans Serpiginosa
J. David Outland, MD;
Timothy S. Brown, MD;
Jeffrey P. Callen, MD
From the University of Louisville, Louisville, Ky.
Arch Dermatol. 2002;138:169-171.
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REPORT OF CASES
CASE 1
A 22-year-old woman presented with a 2-year history of an eruption on
the anterior aspect of her neck and right arm that was relatively asymptomatic.
She had a history of cystinuria, which had been treated with D-penicillamine
for several years, but the D-penicillamine therapy had been discontinued 2
years before the onset of the eruption. A biopsy was performed approximately
1 year before her presentation to our institution. The biopsy specimen demonstrated
clawlike downgrowths of epidermis surrounding collections of amorphous basophilic
debris and hyperplastic elastic fibers. Many elastic fibers were noted to
be pushing through epidermal channels (Figure
1), a finding that was consistent with the clinical diagnosis of
elastosis perforans serpiginosa (EPS). The patient was treated unsuccessfully
with several modalities in a sequential fashion, including liquid nitrogen
cryotherapy monthly for 6 months, topical tretinoin gel . . . [Full Text of this Article] CASE 2
THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
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Kelly and Purcell
Arch Dermatol 2006;142:829-830.
FULL TEXT
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