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In a recent issue of the ARCHIVES, Descamps et al¹ reported an association between severe drug adverse reaction, namely, drug hypersensitivity syndrome, and human herpesvirus 6 (HHV-6) infection. Although it was an interesting report, we noted 2 problems.

First, the authors cited our previous report,² mentioning that "Human herpesvirus 6 genome was detected from peripheral blood mononuclear cells [PBMCs]" in our patient and that the value of the detection "is controversial because it can be present in healthy patients." They misunderstood our result. We isolated HHV-6 from PBMCs in 1 patient. This did not mean that we detected the viral genome in PBMCs. Human herpesvirus 6 DNA is sometimes detected in the PBMCs of healthy adults by polymerase chain reaction. However, HHV-6 is rarely isolated from the PBMCs of healthy subjects. Viral isolation from PBMCs is the most reliable method for diagnosing an active HHV-6 infection.³

Second, we think that . . . [Full Text of this Article]

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Association Between Anticonvulsant Hypersensitivity Syndrome and Human Herpesvirus 6 Reactivation and Hypogammaglobulinemia
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Arch Dermatol 2004;140:183-188.
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