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Hywel C. Williams, PhD

Arch Dermatol. 2002;138:391-392.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Kalliomaki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E
Lancet. 2001;357:1076–1079

Probiotics are cultures of potentially beneficial bacteria of microflora of the healthy gut. Previous epidemiological studies that have suggested that there is an inverse relationship between infections and atopic disease. Kalliomaki and colleagues proposed that specific microbes in the commensal microflora of the gut during early life might be more important than sporadic infections in the prevention of atopic disease. They argue that commensal gastrointestinal microbes are the earliest and biggest stimulus for the development of gut-associated lymphoid tissue that may counter the skewed T_H2 helper cell lymphocyte response that is characteristic of atopic disease. The objective of this double-blind, placebo-controlled, randomized parallel group study was to see whether atopic disease could be prevented in infants at high risk of . . . [Full Text of this Article]

Editor's Comment

Department of Dermatoepidemiology
Centre of Evidence-Based Dermatology
Queen's Medical Centre
Nottingham NG7 2UH, England
(e-mail: hywel.williams@nottingham.ac.uk)

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