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Although Darier disease (DD) may have papillomatous appearance, to our knowledge, no human papillomavirus (HPV) has been reported to be involved. Arotinoid ethylester (p-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) propenyl]-benzoic acid ethyl ester) is one of the third-generation, or polyaromatic, retinoids. We report here the use of arotinoid ethylester in 2 cases of DD and the detection of HPV DNA in biopsy specimens of these cases.

Report of Cases

Two men aged 60 years (case 1) and 41 years (case 2) presented with DD for 20 and 15 years, respectively. Both had crusted papules, plaques, and verrucous lesions nearly all over the body, with papillomatous vegetation pronounced in the flexures (Figure 1). Histologically, suprabasal lacunae and dyskeratosis with corps ronds and grains were consistent with the diagnosis of DD. Biopsy specimens from the vegetative lesions of the 2 cases showed papillomatous proliferation and vacuolated keratinocytes in the upper stratum malpighii, in addition to acantholysis and dyskeratosis . . . [Full Text of this Article]

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