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Denileukin Diftitox for the Treatment of Panniculitic Lymphoma
Karen S. McGinnis, MD;
Michael Shapiro, MD;
Jacqueline M. Junkins-Hopkins, MD;
Mitchell Smith, MD, PhD;
Stuart R. Lessin, MD;
Carmela C. Vittorio, MD;
Alain H. Rook, MD
From the Department of Dermatology, University of Pennsylvania (Drs
McGinnis, Shapiro, Junkins-Hopkins, Vittorio, and Rook); and the Lymphoma
Service, Fox Chase Cancer Center (Drs Smith and Lessin), Philadelphia, Pa.
Arch Dermatol. 2002;138:740-742.
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REPORT OF A CASE
A 24-year-old white woman presented with a 9-month history of proximal
extremity nodules, associated with fevers and arthralgias, that had only a
partial response to a combination of oral prednisone, topical betamethasone
ointment, and topical calcipotriene ointment.
Examination revealed a healthy-appearing woman with a low-grade fever.
There were annular and polycyclic eroded plaques and firm subcutaneous nodules
on her proximal arms and dusky red, atrophic plaques on her right thigh and
the middle of her back (Figure 1A).
Laboratory evaluation revealed a microcytic anemia (hemoglobin, 11.2 g/dL;
mean corpuscular volume, 77 fL) and normal liver function test results. Results
of several skin biopsies showed histological and immunophenotypic features
of subcutaneous panniculitic T-cell lymphoma (Figure 2A and B).
Figure appears in full text version.
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THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Fever and Necrotic Nodules on the Extremities--Diagnosis
Arch Dermatol 2005;141:1035-1040.
FULL TEXT
Phase II Study of Denileukin Diftitox for Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma
Dang et al.
JCO 2004;22:4095-4102.
ABSTRACT
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