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Reviewing the Medical Literature
Statistics Alone Are Not Enough
Arch Dermatol. 2002;138:829-830.
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THE STUDY titled "Oral Treatment for Toenail Onychomycosis" by Crawford
et al1 in this issue of the ARCHIVES has the
objective "to identify and synthesize the evidence for the efficacy and cost-effectiveness
of oral treatments for fungal infections of the toenails." Their ambitious
goal is to examine "all available data from evaluations of these therapies"
and include "a statistical summary of their clinical and cost-effectiveness."
This very thorough search included 11 databases, a hand search of 3 podiatry
journals, searching the bibliographies of all review articles, and contacting
all podiatry schools in the United Kingdom as well as pharmaceutical firms
to identify unpublished or unlisted trials. Rigorous selection criteria were
applied by 4 workers working independently in pairs. All reviewers independently
summarized the trials using 12 quality criteria.
As their therapeutic end point, the authors chose a mycologically negative
nail. Mycologic results of various studies were directly compared and subjected
. . . [Full Text of this Article]
RELATED ARTICLE
Oral Treatments for Toenail Onychomycosis: A Systematic Review
Fay Crawford, Philip Young, Christine Godfrey, Sally E. M. Bell-Syer, Rachel Hart, Elizabeth Brunt, and Ian Russell
Arch Dermatol. 2002;138(6):811-816.
ABSTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Fungal Infections of the Nail: New Perspectives
Bristow
INT J LOW EXTREM WOUNDS 2005;4:72-73.
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