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Evidence for a Premalignant or Reactive Immune Disorder?

Arch Dermatol. 2002;138:1089-1090.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

IN THIS issue of the ARCHIVES, Weinberg and coworkers¹ report studies of T-cell clonality in pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC). They confirm earlier reports that PLEVA is often a clonal T-cell disorder^2-3 and that some cases of PLC are clonal as well.⁴ The authors found a significantly higher frequency of clonal T cells in PLEVA than in PLC and conclude that PLEVA is a benign clonal T-cell disorder arising from a subset of T cells in lesions of PLC. They speculate that a small clonal population of CD8⁺ T cells, usually below the level of detection by polymerase chain reaction amplification, is present in PLC and that a greater influx of CD8⁺ cells results in the detection of clonal T cells and clinical manifestations of PLEVA. Unfortunately, the authors were not able provide direct evidence that lesions of PLEVA are clonally derived from PLC; . . . [Full Text of this Article]

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The Clonal Nature of Pityriasis Lichenoides
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