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T-Cell Clonality in Pityriasis Lichenoides
Evidence for a Premalignant or Reactive Immune Disorder?
Arch Dermatol. 2002;138:1089-1090.
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IN THIS issue of the ARCHIVES, Weinberg and coworkers1
report studies of T-cell clonality in pityriasis lichenoides et varioliformis
acuta (PLEVA) and pityriasis lichenoides chronica (PLC). They confirm earlier
reports that PLEVA is often a clonal T-cell disorder2-3
and that some cases of PLC are clonal as well.4
The authors found a significantly higher frequency of clonal T cells in PLEVA
than in PLC and conclude that PLEVA is a benign clonal T-cell disorder arising
from a subset of T cells in lesions of PLC. They speculate that a small clonal
population of CD8+ T cells, usually below the level of detection
by polymerase chain reaction amplification, is present in PLC and that a greater
influx of CD8+ cells results in the detection of clonal T cells
and clinical manifestations of PLEVA. Unfortunately, the authors were not
able provide direct evidence that lesions of PLEVA are clonally derived from
PLC; . . . [Full Text of this Article]
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