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I agree with the conclusion drawn by Dr Kashani-Sabet and colleagues in their article titled "Vascular Involvement in the Prognosis of Primary Cutaneous Melanoma"¹ and expressed by them as follows:

The results of our analysis clearly indicate the independent role of vascular involvement in the prognostic assessment of patients with melanoma. The presence of vascular involvement was associated with an increased risk of melanoma relapse and death. Interestingly, involvement of the tumor vasculature, which is believed to represent largely lymphatic vessels, was predictive of distant as well as regional nodal metastases. . . . Prior studies of definite vascular invasion have suggested the high-risk nature of this prognostic factor.

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