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Basiliximab is a chimeric (of human and murine origins) monoclonal antibody directed to the interleukin 2 receptor and is directly able to prevent T-cell activation. Theoretically, therefore, it should be of benefit in patients affected by T-cell–mediated autoimmune diseases and, in particular, by lichen planus. The outcome of a patient of ours suggests that this may be the case.

Report of a Case

A 67-year-old diabetic woman with severe erosive lichen planus of the mouth and vagina (the vaginal orifice was reduced to <1 cm in diameter) had been taking oral cyclosporine for 2 years. The initial dose (5 mg/kg per day) was tapered, but never went below 150 mg/d, lest the lesions might worsen. Whenever a further diminution was tried, the patient became unable to eat and speak. In addition, although there was no sign of renal function impairment, an impressive gum hyperplasia developed. The withdrawal of cyclosporine and the introduction of a . . . [Full Text of this Article]

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Mucocutaneous Lichen Planus With Esophageal Involvement: Successful Treatment With an Anti-CD20 Monoclonal Antibody
Parmentier et al.
Arch Dermatol 2008;144:1427-1430.
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