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A 21st-Century Perspective

Arch Dermatol. 2003;139:66-70.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

ACTINIC keratoses are proliferations of transformed, neoplastic keratinocytes that are confined to the epidermis and induced by exposure to UV radiation in sunlight. Neoplastic transformation occurs in keratinocytes that have been exposed to UV radiation and is due primarily to mutations in the p53 gene. In time, these cells proliferate in the epidermis and eventually extend into the dermis, at which point metastatic spread can occur. Cytologic atypia is visible in early stages and is identical to that seen in metastatic lesions or in squamous cell carcinoma in the dermis. While these cells remain confined to the epidermis, the lesions that they cause are termed actinic keratoses, but when they extend more deeply to involve the papillary and/or reticular dermis, they are termed squamous cell carcinoma. The term actinic keratosis was developed on the basis of the clinical appearance and texture of these lesions, without regard to histopathologic or . . . [Full Text of this Article]

PATHOGENESIS


CLINICAL PRESENTATION

BIOLOGIC BEHAVIOR

HISTOPATHOLOGIC FEATURES

THE RELATIONSHIP BETWEEN AK AND SCC

PROPOSED REVISED NOMENCLATURE FOR AKs

COMPARISON OF KIN LESIONS AND INTRAEPITHELIAL NEOPLASMS OF THE FEMALE REPRODUCTIVE TRACT

TREATMENT

CONCLUSIONS

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