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The Road to Understanding the Complex Nature of Adipose Tissue and Lipoatrophy

Arch Dermatol. 2003;139:81-83.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE LIPODYSTROPHIES, a group of disorders characterized by loss of adipose tissue in various distributions, are associated with an assortment of metabolic abnormalities, predominately insulin resistance, hypertriglyceridemia, and fatty liver. To better understand the role of adipose tissue in the development of diabetes and obesity, transgenic mice, or gene knockout mice, have been produced that mimic the human forms of lipodystrophy. The study of these mice and adipocytes in general, which are now known to produce a variety of bioactive molecules, has transformed the view of the adipocyte from a passive storage cell to a more complex one functioning as a secretory and endocrine tissue that may also be linked to the immune system.
Arch Dermatol. 2003;139:81-83

The lipodystrophies are a group of disorders characterized by loss of adipose tissue. They are classified according to the extent of fat loss and whether they are genetic or acquired.¹ All lipodystrophies may . . . [Full Text of this Article]

FAMILIAL AND ACQUIRED LIPODYSTROPHIES


MOUSE MODELS OF LIPODYSTROPHY


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