This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal

Arch Dermatol. 2003;139:93-98.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Nevus comedonicus (NC).

MICROSCOPIC FINDINGS

Microscopic examination revealed epidermal invaginations filled with keratin in concentric lamellae. Follicular walls showed changes of epidermolytic hyperkeratosis, including hypergranulosis, vacuolar degeneration of the granular cells, and irregular keratohyalin bodies.

DISCUSSION

Nevus comedonicus was first described by Kofman¹ in 1895. It has been suggested that NC is an uncommon type of adnexal hamartoma, with abnormal differentiation of the epithelial portion.² The follicular structure that results is unable to form terminal hair or sebaceous glands and is capable of producing only soft keratin, which accumulates in the adnexal orifices.² The NC syndrome is characterized by skeletal, ocular, and central nervous system defects.³

Nevus comedonicus demonstrates no sex or race predilection, and while 50% of cases are evident at birth, lesions may appear during childhood or even later.² Clinically, NC demonstrates clusters of dilated follicular openings filled with keratin, giving the appearance of open comedones. Nevus comedonicus of the thigh is very rare. . . . [Full Text of this Article]

RELATED ARTICLE

Two Dark Plaques on the Thigh—Quiz Case
Susana Machado, Elvira Silva, Virgílio Costa, Isabel Calhim, and António Massa
Arch Dermatol. 2003;139(1):93-98.
EXTRACT | FULL TEXT