This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Diagnosis  • Dermatologic Disorders, Other  • Alert me on articles by topic

Arch Dermatol. 2003;139:1363-1368.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagonsis: Keratoacanthoma visceral carcinoma syndrome (KAVCS).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Hematoxylin-eosin staining of a biopsy specimen of a large nodule that had been excised showed an exoendophytic crater-shaped neoplasm with keratin-filled channels lined by pale epithelium with a ground glass–like cytoplasm and surrounded by a sparse inflammatory infiltrate, characteristic of keratoacanthoma. Microscopic examination of the atrophic portion of the annular plaque on the left arm showed an epidermis with blunted rete ridges and an expanded papillary dermis with melanophages and slightly hyalinized collagen bundles, consistent with regression. Tissue cultures for bacteria, fungi, and atypical mycobacteria were unremarkable. The large plaque on the patient's left arm was thought to be consistent with keratoacanthoma centrifugum marginatum, and the diagnosis of KAVCS was made.

One month after excision of the nodule, a large hyperkeratotic plaque was found at the site. It was followed up clinically and in 2 months spontaneously regressed into a red atrophic scar. Because of the number of lesions, the . . . [Full Text of this Article]

DISCUSSION

RELATED ARTICLE

Multiple Hyperkeratotic Nodules on the Arms—Quiz Case
Michael M. Todd, Christie T. Ammirati, Elizabeth M. Billingsley, Jeffrey J. Miller, and Klaus F. Helm
Arch Dermatol. 2003;139(10):1363-1368.
EXTRACT | FULL TEXT