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Topical Tacrolimus Ointment Is an Effective Therapy for Hailey-Hailey Disease
Carsten Sand, MD, DMSc;
Henrik Klem Thomsen, MD, DMSc
From the Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Arch Dermatol. 2003;139:1401-1402.
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REPORT OF A CASE
A 67-year-old man with a 10-year history of flexural blistering eruptions also affecting 3 of his brothers was first evaluated in 1987. The patient presented with vesicles, erosions, and erythema in the intertriginous areas but also as multiple truncal plaques (Figure 1). Biopsy specimens showed intraepidermal clefts of varying sizes both suprabasally and higher in the epidermis, as well as the characteristic incomplete acantholysis in large parts of the epidermis, giving it the appearance of a "dilapidated brick wall" (Figure 2). The findings of a direct immunofluorescence evaluation were negative, which is consistent with a diagnosis of Hailey-Hailey disease (or chronic benign familial pemphigus).
Figure appears in full text version.
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Figure 1. Hailey-Hailey disease with truncal lesions before treatment with 0.1% tacrolimus ointment.
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Figure appears in full text version.
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Figure 2. A cleft is present within the epidermis, and the epithelium beneath the cleft shows partial acantholysis (hematoxylin-eosin, original . . . [Full Text of this Article]
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THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Is Topical Tacrolimus Really an Effective Therapy for Hailey-Hailey Disease?
Laffitte and Panizzon
Arch Dermatol 2004;140:1282-1282.
FULL TEXT
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