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Arch Dermatol. 2003;139:1497-1502.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Cutaneous metastasis from renal cell carcinoma.

MICROSCOPIC FINDINGS AND CLINICAL COURSE

The biopsy specimen showed a dense, diffuse infiltrate of large cells located in the entire dermis and subcutis, sparing the epidermis. The infiltrating neoplastic cells had a polyhedral shape, central pale nuclei, and abundant clear cytoplasm. Periodic acid–Schiff–positive granules were detected within the cytoplasm of the cells before but not after digestion with diastase, and immunohistochemical staining was positive for AE1/AE3 cytokeratins. These findings were consistent with the diagnosis of cutaneous metastasis, although the patient did not have a history of cancer.

A workup was performed to help find the primary source of the cutaneous metastasis. Routine laboratory investigations revealed hypochromic anemia (hemoglobin, 8.7 g/dL [reference range: 13-18 g/dL]; red blood cell count, 3.0 x 10⁶/µL [reference range, 4.4-6.0 x 10⁶/µL]), as well as high levels of serum creatinine (2.6 mg/dL [230 µmol/L] [reference range, 0.6-1.2 mg/dL (53-106 µmol/L)]), urea nitrogen (137 mg/dL [97.8 mmol/L] [reference range, 10-50 . . . [Full Text of this Article]

DISCUSSION

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Arch Dermatol. 2003;139(11):1497-1502.
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