Diagnosis: Multiple fibrofolliculomas.
MICROSCOPIC FINDINGS
The hematoxylin-eosin–stained sections revealed a normal epidermis and perifollicular epithelial proliferation arranged in anastomosing strands within well-circumscribed fibrous stroma in the dermis. These histopathologic findings were consistent with fibrofolliculoma.
DISCUSSION
Multiple fibrofolliculomas usually occur as part of an uncommon autosomal dominant disorder in which patients develop multiple asymptomatic papules on the face, neck, and axillae during adulthood.1 The papules are considered to be benign hamartomas that are characterized histopathologically by a central dilated hair follicle with numerous thin, anastomosing bands of follicular epithelium that extend into a thick mantle of stroma. This pilar tumor has both ectodermal and mesodermal components. Fibrofolliculoma may also present as a solitary papule on the face.1
Multiple fibrofolliculomas, along with trichodiscomas and acrochordons (skin tags), compose the triad of Birt-Hogg-Dubé syndrome, which was first reported in 1977.2 This syndrome also demonstrates autosomal dominant inheritance and has been mapped to chromosome 17p11.2.3 Trichodiscomas are clinically indistinguishable from . . . [Full Text of this Article]
