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Taking Advantage of a Side Effect of Isotretinoin
Claudio Cortese, MD;
Rosamaria Corona, DSc, MD
Arch Dermatol. 2003;139:376-377.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Commentary on: High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study
Rodondi N, Darioli R, Ramelet AA, Hohl D, Lenain V, Perdrix J, Wietlisbach V, Riesen WF, Walther T, Medinger L, Nicod P, Desvergne B, Mooser V
Ann Intern Med. 2002;136:582-589
Question: Do young adults who develop hypertriglyceridemia after isotretinoin therapy for acne have an inherited predisposition to develop familial combined hyperlipidemia (FCHL) and the metabolic syndrome?
Objective: To explore the hypothesis that the hyperlipidemic response to isotretinoin is genetically determined and that isotretinoin unmasks the genetic predisposition of some individuals to develop FCHL or a component of the metabolic syndrome.
Design: Case-control study. "Cases" (hyperresponders) were persons whose triglyceride level increased during treatment by 89 mg/dL or more ( 1.0 mmol/L), corresponding to the upper quintile . . . [Full Text of this Article] Comment
Department of Internal Medicine, University of Rome "Tor Vergata" (Dr Cortese), and Istituto Dermopatico dell'Immacolata (Dr Corona), Rome, Italy
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