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Plaque on the Thigh of a Renal Transplant RecipientDiagnosis
Arch Dermatol. 2003;139:381-386.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Diagnosis: Kaposi sarcoma (KS), lymphangiomalike variant.
MICROSCOPIC FINDINGS
The biopsy specimen revealed ectatic, bizarrely shaped vascular spaces that were incompletely lined with endothelial cells. In some areas, normal blood vessels protruded into newly formed vessels (the promontory sign). Erythrocytes were detected inside some of the spaces.
DISCUSSION
Kaposi sarcoma is an endothelial cell tumor that is believed to be caused by infection with human herpesvirus 8.1 Patients receiving immunomodulatory medication for various indications, such as organ transplantation, autoimmune diseases, or malignancies, are prone to develop KS.2-4 This phenomenon is seen in as many as 3% to 6% of renal transplant recipients, with a mean period of 20 months of immunosuppressive therapy prior to the development of KS.5-6 Cyclosporine therapy carries a higher risk for development of KS than azathioprine and prednisone therapy.6 However, even the use of prednisone alone2, 7 is related to an increased risk for development of KS.2 It is well documented that this type of KS responds . . . [Full Text of this Article]
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Arch Dermatol. 2003;139(3):381-386.
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