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Treatment of Cutaneous Leishmaniasis With Photodynamic Therapy
Claes D. Enk, MD, PhD;
Clemens Fritsch, MD;
Flory Jonas, BSc;
Abedelmajeed Nasereddin, MPH;
Arieh Ingber, MD;
Charles L. Jaffe, PhD;
Thomas Ruzicka, MD, PhD
From the Hadassah-Germany Skin Center, Hadassah Medical Organization–Hebrew University Medical School (Drs Enk and Ingber and Ms Jonas), and Hebrew University–Hadassah Medical School (Drs Nasereddin and Jaffe), Jerusalem, Israel, and Heinrich Heine University, Dusseldorf, Germany (Drs Fritsch and Ruzicka).
Arch Dermatol. 2003;139:432-434.
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INTRODUCTION
Old World cutaneous leishmaniasis,1 which is found in widely scattered parts of Asia, Africa, and Europe, is the result of leishmanial infection of dermal macrophages. Leishmania major is the most common cause of cutaneous leishmaniasis in the Middle East. The cutaneous lesions occur at the site of the Phlebotomus sandfly bite and within a few months develop from small erythematous papules to larger dusky granulomatous lesions, often with ulcerated centers and raised indurated borders. The lesions may heal spontaneously over months to years, often leaving disfiguring, slightly depressed scars.
REPORT OF CASES
Eleven consecutive Israeli patients with a total of 32 lesions of cutaneous leishmaniasis were included in the study. The clinical diagnosis was verified by demonstration of amastigotes in direct smears from the lesions. Leishmania species characterization . . . [Full Text of this Article]
THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Photodynamic Sensitization of Leishmania amazonensis in both Extracellular and Intracellular Stages with Aluminum Phthalocyanine Chloride for Photolysis In Vitro
Dutta et al.
Antimicrob. Agents Chemother. 2005;49:4474-4484.
ABSTRACT
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