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Multiple Erythematous Plaques on a Child—Diagnosis
Arch Dermatol. 2003;139:531-536.
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Diagnosis: Acute hemorrhagic edema (AHE) of infancy.
MICROSCOPIC FINDINGS AND CLINICAL COURSE
The initial biopsy specimen, obtained on the 10th day of disease, demonstrated leukocytoclastic vasculitis. Microscopic examination of the second biopsy specimen showed a moderate perivascular infiltrate of histiocytes with relatively plentiful cytoplasm, a few multinucleated histiocytes, some neutrophils, and rare eosinophils. The histiocytic cells stained with antibodies against factor XIIla antigen and showed negative staining for CDla antigen and S100 protein.
The patient's skin lesions regressed spontaneously within 1 month after his visit, leaving a slight atrophy in some areas.
DISCUSSION
Acute hemorrhagic edema of infancy is a self-healing, unusual variant of leukocytoclastic vasculitis that affects infants between the ages of 4 and 24 months.1-8 The cause of this disease is still unknown, but there is frequently a history of an upper respiratory tract infection,1-4,6-7 as was noted in the present case. The presence of a history of an upper respiratory tract infection and the seasonal variation of the disease, with . . . [Full Text of this Article]
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Arch Dermatol. 2003;139(4):531-536.
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