This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Diagnosis  • Dermatologic Disorders, Other  • Alert me on articles by topic

Arch Dermatol. 2003;139:803-808.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Cryoglobulinemia associated with multiple myeloma.

MICROSCOPIC, LABORATORY, AND RADIOGRAPHIC FINDINGS AND CLINICAL COURSE

Histologic findings in the 2 skin biopsy specimens were similar. Multiple thrombi were seen within blood vessels in the superficial and deep dermis; several of the thrombi had a hyalinized appearance. There were also scattered neutrophils in and around the vessels, with hemorrhage and proliferation of capillaries in small lobules. The dermatopathologist raised the possibility of monoclonal cryoglobulinemia.

When a serum sample was cooled to 4°C, a gelatinous cryoprecipitate formed (Figure 4, from left to right: positive control, patient's serum, and negative control samples, all at 4°C) and disappeared when the sample was rewarmed. A cryocrit could not be determined because the sample became completely gelled. The results of additional laboratory investigations were negative or within normal limits: anticardiolipin antibody, lupus anticoagulant, Russell viper venom clotting time, serum viscosity at 37°C, rheumatoid factor, and serologic tests for hepatitis A, B, and C. There was a transient decrease of . . . [Full Text of this Article]

DISCUSSION

RELATED ARTICLE

Retiform Purpura—Quiz Case
Marlyanne M. Pol-Rodriguez, Saara Crane, Dennis L. Feinberg, Earl J. Glusac, and Jean L. Bolognia
Arch Dermatol. 2003;139(6):803-808.
EXTRACT | FULL TEXT