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Arch Dermatol. 2003;139:926-928.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

PATIENTS WITH cutaneous lymphoma present to dermatologists with malignant exaggerations of cutaneous lymphocyte biological features.¹ The puzzles presented by cutaneous T-cell lymphomas (CTCLs) are actively being pursued to understand and, one hopes, to exploit the regulation of cutaneous T cells. In the immunoregulatory repertoire of the skin are the answers to atopic dermatitis, psoriasis, contact sensitivity, and most inflammatory disorders that also present to dermatologists. The lure of understanding T-cell regulation by way of CTCL has even attracted criminal activities. One group of CTCL investigators was convicted of fraud when they uttered their version of "eureka."² Still, there are few shouts of discovery. The answers can only be achieved in a stepwise approach. The accompanying article by Kim et al³ is a fitting memorial to the extent of information available from retrospective observational studies of CTCL. The key points of that article lead us to visualize the next steps: the . . . [Full Text of this Article]

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