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Arch Dermatol. 2003;139:933-938.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Eosinophilic cellulitis (Wells syndrome).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Microscopic examination showed acanthosis, mild spongiosis, and parakeratosis of the epidermis and focal collections of polymorphic leukocytes within the stratum corneum. A superficial and deep perivascular infiltrate was present, composed predominantly of eosinophils, admixed with lymphocytes and histiocytes. No vasculitis or parasites were present, and a methenamine silver stain was negative for fungi. These findings were diagnostic of eosinophilic cellulitis.

Oral prednisone therapy was initiated at a dosage of 40 mg/d. The patient's symptoms began to resolve rapidly, and he was discharged the following day on a tapering regimen of oral prednisone.

DISCUSSION

Eosinophilic cellulitis was first described by Wells¹ in 1971. It is characterized by inflammatory cutaneous lesions that initially resemble bacterial cellulitis but fail to respond to antibiotic therapy and that are composed predominantly of eosinophils. Lesions of Wells syndrome typically develop rapidly, resolve spontaneously, recur frequently, and are rarely accompanied by systemic symptoms such as fever.^2-3 Peripheral eosinophilia, . . . [Full Text of this Article]

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Arch Dermatol. 2003;139(7):933-938.
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