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Rash With Regional LymphadenopathyDiagnosis
Arch Dermatol. 2003;139:1075-1080.
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Diagnosis: Localized cutaneous leishmaniasis.
MICROSCOPIC, RADIOLOGIC, AND LABORATORY FINDINGS AND CLINICAL COURSE
Histologic examination revealed a dense dermal infiltrate composed predominantly of histiocytes and lymphocytes with scattered plasma cells forming, in areas, an ill-defined granulomatous component. Within histiocytes, there were occasional intracytoplasmic 2- to 4-µm organisms consistent with Leishmania species (Figure 3). A computed tomographic scan revealed a left lower thoracic lymphatic cord and a 2.5-cm left inguinal lymph node. Culture on Novy-MacNeal-Nicolle medium from the Centers for Disease Control and Prevention confirmed the species as Leishmania viannia panamensis (formerly known as Leishmania braziliensis panamensis).
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Our patient received 3 days of treatment with liposome-encapsulated amphotericin B before therapy with the pentavalent ammonial compound sodium stibogluconate (Pentostam) was initiated, with the intent to treat at a dosage of 1600 mg/d for 20 days. A response to treatment was evident by day 4 of the sodium stibogluconate therapy, with a decrease in the erythema and induration of the skin . . . [Full Text of this Article] DISCUSSION
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Rash With Regional LymphadenopathyQuiz Case
Valentina R. Bradley, Vincent Liu, and Harley A. Haynes
Arch Dermatol. 2003;139(8):1075-1080.
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