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Arch Dermatol. 2003;139:1209-1214.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Amelanotic desmoplastic neurotropic melanoma (DNM) of the nose.

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Microscopic examination revealed a dermal, amelanotic spindle cell proliferation arranged in whorls, infiltrating the entire reticular dermis. The fascicles had no contact with the overlying epidermis. Higher magnification showed nuclear pleomorphism, hyperchromatism, scattered mitoses, and marked stromal desmoplasia with a focal lymphoid inflammatory infiltrate. The depth of invasion of the tumor was Clark level IV, while the Breslow thickness was 3 mm. Immunohistochemical stains were positive for S100 protein, HMB-45, and vimentin. Stains for other markers, such as actin, cytokeratin, desmin, and epithelial membrane antigen, were all negative.

A wide excision was performed with a margin of 0.5 cm. A sentinel node, found in the right side of the neck, showed a reactive lymphadenitis without tumor infiltration. After 21 months of follow-up, the patient was free of disease.

DISCUSSION

Desmoplastic neurotropic melanoma is a rare variant of desmoplastic cutaneous melanoma.¹ Since the original description by Reed and Leonard² in 1979, fewer . . . [Full Text of this Article]

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Arch Dermatol. 2003;139(9):1209-1214.
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