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Arch Dermatol. 2004;140:1393-1398.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Iododerma.

MICROSCOPIC FINDINGS AND CLINICAL COURSE

A skin biopsy specimen obtained from an early pustular lesion showed focal subepidermal and intraepidermal vesicle formation, a dense neutrophilic infiltrate involving the entire dermis and extending into the subcutaneous tissue, and prominent leukocytoclasis and fibrinoid changes in the walls of small blood vessels. Direct immunofluorescence studies showed strong staining with IgG and IgA in the superficial and middermal vessels and with fibrinogen in the superficial dermal vessels. Special staining of the tissue sections did not demonstrate any bacterial or fungal organisms.

The patient was initially empirically treated with antibacterial agents and acyclovir. Methylprednisolone sodium succinate (Solu-Medrol, 60 mg/d) was added to her regimen 1 day later because she had developed mild hoarseness and her skin lesions had not improved. On hospital day 3, she was started on a 3-day course of pulse methylprednisolone (1 g/d) for the development of new hemorrhagic bullae on her extremities. Dapsone (100 mg/d) was . . . [Full Text of this Article]

DISCUSSION