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COMMENTS AND OPINIONS
Nephrogenic Fibrosing Dermopathy: Are ACE Inhibitors the Missing Link?
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Nephrogenic fibrosing dermopathy (NFD) is a recently described cutaneous fibrosing disorder seen exclusively in patients with renal failure.1 This entity is characterized by progressive skin hardening and induration and differs from scleromyxedema by the absence of plasma cells on histologic evaluation and a lack of paraproteinemia. It differs from scleroderma in its morphology, distribution, histopathology, and in lacking anti–Scl-70 antibodies.1
This disease has been reported in patients with renal failure regardless of whether they are receiving hemodialysis. No single treatment has been shown to be effective in all cases of NFD, although plasmapheresis, thalidomide, extracorporeal photopheresis, and others have been reported to be effective in some patients. It is unclear why NFD has come to the attention of dermatologists only recently, despite the long history of renal failure and hemodialysis.
We uncovered a striking commonality among 7 patients with NFD for whom we cared at our institution and patients described . . . [Full Text of this Article]
AUTHOR INFORMATION
Amin Fazeli, MD, PhD;
Peter A. Lio, MD;
Vincent Liu, MD
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