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Arch Dermatol. 2004;140:353-358.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Multiple granular cell tumors (GCTs).

MICROSCOPIC FINDINGS

Light microscopic examination of the biopsy specimen revealed irregular epidermal hyperplasia associated with a dermal proliferation consisting of aggregates of cells demonstrating a predominantly lobular growth pattern The constituent round and polyhedral cells were monotonous, with abundant eosinophilic granular cytoplasm and distinct cell borders. Some cells demonstrated pustulo-ovoid bodies of Milian in the cytoplasm (Figure 3). The nuclei were typically centrally placed, small, and often slightly hyperchromatic with inconspicuous nucleoli. Mitotic figures were absent.

Figure appears in full text version. Figure 3.

DISCUSSION

Granular cell tumors are most often diagnosed as isolated nodules in adults aged 30 to 50 years. They sometimes appear on the tongue but most commonly arise in the skin.^1-2 Less frequently, they occur as multiple tumors. They rarely develop in childhood, with fewer than 30 cases of multiple juvenile GCTs having been reported to date.^3-6 The literature suggests that the syndrome of multiple GCTs is more common in black individuals.³

Cases . . . [Full Text of this Article]

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Arch Dermatol. 2004;140(3):353-358.
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