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Successful Treatment of Invasive Squamous Cell Carcinoma Using Topical Imiquimod
Ulrich R. Hengge, MD;
Jörg Schaller, MD
From the Heinrich-Heine-University, Duesseldorf (Dr Hengge), and St Barbara Hospital, Duisburg (Dr Schaller), Germany.
Arch Dermatol. 2004;140:404-406.
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REPORT OF A CASE
A 65-year-old man with a history of renal transplantation, chronic renal insufficiency after graft failure, and hemodialysis presented with a red palpable lesion on his right temple that had developed over a 3-year period (Figure 1A). The 4 x 3-cm erythematous hyperkeratotic plaque was located at the hair rim. On palpation, some induration and several papules were noted. Histologic examination of a 5-mm punch biopsy specimen showed tumor cells with variably irregular nuclei and several atypic mitoses that extended into the dermis (Figure 2A).
Figure appears in full text version.
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Figure 1. A, Erythematous, hyperkeratotic plaque (4 x 3 cm) of 3 year's duration on the right temporal aspect of the hair rim. B, At week 4, initial regression is evident at the borders, while the central erythema persists. C, At week 16, a scar is seen at the lesion site.
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Figure appears in full text version.
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THERAPEUTIC CHALLENGE
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