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  Vol. 140 No. 4, April 2004 TABLE OF CONTENTS
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Periodic Fever With Atypical Dyshidrosis—Diagnosis

Arch Dermatol. 2004;140:479-484.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Leukemic mycosis fungoides.

MICROSCOPIC AND LABORATORY FINDINGS

The patient's laboratory examination revealed a white blood cell count of 60.3 x 103/µL (reference range, 3.4-9.6 x 103/µL) consisting of 80% atypical lymphocytes characterized by cerebriform nuclei (Figure 4). Flow cytometry of a peripheral blood sample revealed T cells expressing the {alpha}{beta} T-cell receptor with the following abnormalities: coexpression of CD4 and CD8, uniformly strong expression of CD7, and weak expression of CD25. The sedimentation rate was elevated at 50 mm/h (50 mm/h; reference value, <40 mm/h) as were the levels of serum urea nitrogen (32 mg/dL [11.4 mmol/L]; reference range, 8-22 mg/dL [2.9-7.9 mmol/L]) and serum creatinine (2.5 mg/dL [221 µmol/L]; 0.7-1.3 mg/dL [62-115 µmol/L]). Serologic tests were negative for human T-cell lymphotropic virus 1.


 
Figure appears in full text version.
Figure 4.


Histologic examination of a sample of involved skin showed a prominent dermal lymphoid infiltrate with epidermotropism. The majority of the infiltrating T cells were CD3 positive, CD4 positive, . . . [Full Text of this Article]

DISCUSSION



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