Diagnosis: Lymphomatoid papulosis (LyP).
MICROSCOPIC FINDINGS AND CLINICAL COURSE
Histopathologic examination of a papule showed a wedge-shaped dense infiltrate involving the entire dermis and composed of medium- to large-sized atypical lymphocytes. The atypical lymphocytes were admixed with histiocytes, small lymphocytes, and neutrophils and had abundant cytoplasm and prominent nucleoli. Immunohistochemical investigations revealed that the atypical lymphoid cells stained positively for anti-CD3, -CD4, -CD45RO, and -CD30 (Figure 4) antibodies. These features were consistent with type A LyP.
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Methylprednisolone therapy (16 mg/d for 3 weeks) was initiated, and there was complete remission of the cutaneous lesions by the end of treatment. A few recurrent papules were observed on follow-up 4 months after the patient's initial presentation.
DISCUSSION
Lymphomatoid papulosis is a chronic recurrent papulonodular skin eruption preferentially involving the trunk and extremities, although occurrence on the face, scalp, palms, and soles, as well as mucosal involvement, has been reported.1-2 A few days after their initial appearance, cutaneous lesions . . . [Full Text of this Article]