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Adjacent Dermal Nodules on the NoseDiagnosis
Arch Dermatol. 2004;140:609-614.
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Diagnosis: Benign nodular hidradenoma.
MICROSCOPIC FINDINGS
The microscopic appearance of both nodules was similar. Histologic analysis showed a benign skin appendage tumor that was composed of well-circumscribed nodules situated within the dermis (Figure 2). The nodules were partly solid and partly cystic. The solid areas consisted of cells with small regular nuclei. Mitoses were very frequent. Focal ductal differentiation was present (Figure 3). Immunhistochemical studies showed focal positive staining for CAM 5.2, epithelial membrane antigen, cytokeratin 7, and cytokeratin 19.
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DISCUSSION
Benign nodular hidradenoma is a skin appendage tumor that is characterized by sweat gland differentiation and usually classified as eccrine in origin. It has also been termed solid/cystic hidradenoma, eccrine acrospiroma, clear cell hidradenoma, and eccrine sweat gland adenoma.
The clinical and pathologic features of benign nodular hidradenoma have been defined in several publications.1-5 It is an uncommon tumor, with a female-male ratio of approximately . . . [Full Text of this Article]
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Adjacent Dermal Nodules on the NoseCase
Jane Ravenscroft, Iain Leach, and Sandeep Varma
Arch Dermatol. 2004;140(5):609-614.
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