The End of the Sunscreen and Melanoma Controversy?
Michael E. Bigby, MD
Arch Dermatol. 2004;140:745-746.
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Commentary on: Sunscreen use and the risk for melanoma: a quantitative review
Dennis LK, Beane Freeman LE, VanBeek MJ
Ann Intern Med. 2003;139:966-978
Question: What is the strength and consistency of associations between melanoma and sunscreen use in the published literature?
Data Sources: A comprehensive MEDLINE search of articles published from 1966 to 2003 that reported information on sunscreen use and melanoma in humans.
Study Selection: Analytic studies reporting data on sunscreen use before diagnosis of melanoma.
Data Extraction: Two independent reviewers extracted data. Inconsistencies were reviewed until agreement was achieved. When necessary, a third party resolved discrepancies.
Data Synthesis: Odds ratios were pooled across studies by using standard meta-analytic techniques. Pooled odds ratios for "ever use" among 18 heterogeneous studies did not support an association between melanoma and sunscreen use. Variation among odds ratios was explained by studies that did not adjust for confounding effects . . . [Full Text of this Article] Comment
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Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Mass
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