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Enlarging Congenital Pigmented Plaque—Diagnosis
Arch Dermatol. 2004;140:751.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Diagnosis: Unusual, continuous, plaque-type neurofibroma in segmental neurofibromatosis (SNF) simulating a giant congenital nevus.
MICROSCOPIC FINDINGS
Both the macular and the infiltrative biopsy specimens showed the same pathologic features. Examination of hematoxylin-eosin–stained histologic sections demonstrated a spindle cell process involving dermis and subcutaneous tissue. The tumor was well circumscribed and composed of uniform, bland-appearing cells, some of which had a wavy nucleus. There was mucin between the spindle cells. There were no melanophages or increase in melanin or melanocytes either epidermally or dermally. The findings were characteristic of a neurofibroma.
DISCUSSION
Segmental NF is a mosaic form of NF that results from a mutation during early development that produces 2 different cell populations and therefore 2 different clinical expressions. The degree of expression of SNF depends on the timing of the mutation. Most patients with SNF present with unilateral arrays of discrete neurofibromas, usually conforming to Blaschko lines. Clusters of café au lait macules are the second most common presentation of SNF; a single large neurofibroma is . . . [Full Text of this Article]
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Arch Dermatol. 2004;140(6):751.
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