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Arch Dermatol. 2004;140:751.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Primary cutaneous B-cell lymphoma of the nose.

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Sections of skin showed a dense and diffuse dermal infiltrate of small atypical lymphocytes (Figure 2). Epitheliotropism was not seen. Immunohistochemically, the majority of the cells marked as B lymphocytes (CD20 positive), with a lesser number of individually scattered T lymphocytes (CD3 positive). The cells diffusely expressed bcl-2 protein. Occasional lymphocytes expressed bcl-6 protein, and the cells were immunonegative for CD5, CD10, and and chains. An immunoglobulin heavy-chain gene rearrangement was detected by polymerase chain reaction. These histopathologic, immunophenotypic, and molecular findings were consistent with B-cell lymphoma of follicle center origin.

Figure appears in full text version. Figure 2.

A complete blood cell count, a comprehensive metabolic profile, and liver function test results were all within normal limits. A chest radiograph and computed tomograms of the head, chest, abdomen, and pelvis revealed no abnormalities. The patient was referred to the hematology-oncology clinic, where a bone marrow aspirate revealed atypical lymphoid aggregates scattered throughout the . . . [Full Text of this Article]

DISCUSSION

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Arch Dermatol. 2004;140(6):751.
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