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Hurst and colleagues'¹ recent review entitled "Ocular Melanoma: A Review and the Relationship to Cutaneous Melanoma" had several relevant omissions. Regarding the co-occurrence of cutaneous and ocular melanomas, we published data² from the US Surveillance, Epidemiology and End Results (SEER) database experience with 59 222 cutaneous, 2517 uveal, and 153 conjunctival melanomas (the latter of which comprise at least 85% and 5% of all ocular melanomas, respectively³).

Persons with a history of uveal melanoma were 4.6 times (95% confidence interval, 2.9-6.8) more likely than the general population to develop cutaneous melanoma, although persons with cutaneous melanoma did not develop uveal melanoma at an appreciably elevated rate (standardized incidence ratio, 1.4; 95% confidence interval, 0.5-3). This asymmetric relationship was subsequently reproduced in another population-based registry, the Swedish Family-Cancer Database,⁴ and hypotheses for the relationship put forth.^{2, 4-5} If an etiology such as sun exposure is considered, it may be that persons with . . . [Full Text of this Article]

Andrew R. Shors, MD, MPH; Noel S. Weiss, MD, DrPH

Correspondence: Dr Shors, Division of Dermatology, University of Washington Medical Center, Box 356524, Seattle, WA 98195-6524 (ashors@u.washington.edu).

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