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VIGNETTES
Alcohol-Induced Application Site Erythema After Topical Immunomodulator Use and Its Inhibition by Aspirin
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The topical immunomodulators tacrolimus and pimecrolimus have proven effective in managing atopic dermatitis.1-2 Reported adverse effects are infrequent and most often consist of transient burning, warmth, or erythema at the application site upon initial use.1-2 We recently identified 3 patients who experienced application site erythema following the consumption of alcohol after using topical tacrolimus or pimecrolimus for the treatment of facial dermatoses. While this reaction has sometimes been mentioned for topical tacrolimus,3 there are no reports in the literature of this effect occurring with topical pimecrolimus. To study potential ways of alleviating this unwanted response, we conducted a double-blind controlled evaluation of 2 of the 3 patients after blocking 2 important mediators of vasodilatation, histamine and prostaglandins.
Methods
On days 1 through 12, participants applied 4 randomly coded preparations (0.1% tacrolimus ointment, 1.0% pimecrolimus cream, a control ointment, and a control cream) twice daily to 4 designated locations on the face . . . [Full Text of this Article]
Results
Comment
Benjamin D. Ehst, MD, PhD;
Erin M. Warshaw, MD
Correspondence: Dr Warshaw, Department 111K Dermatology, Veterans Affairs Medical Center, Veterans Dr, Minneapolis, MN 55417 (erin.warshaw@med.va.gov).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Alcohol ingestion and topical tacrolimus: a disulfiram-like interaction?
Morales-Molina et al.
The Annals of Pharmacotherapy 2005;39:772-773.
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