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Melanoma Margins: The Importance and Need for More Evidence-Based Trials
Timothy M. Johnson, MD
Vernon K. Sondak, MD
Arch Dermatol. 2004;140:1148-1150.
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Commentary on: Excision margins in high-risk malignant melanoma
Thomas JM, Newton-Bishop J, A'Hern R, et al, for the United Kingdom Melanoma Study Group, the British Association of Plastic Surgeons, and the Scottish Cancer Therapy Network
N Engl J Med. 2004;350:757-766.
Question: In patients with primary cutaneous melanoma 2 mm or thicker, is there a significant difference in recurrence and/or survival for excision with 1- vs 3-cm margins?
Design: Thomas and colleagues conducted a randomized clinical trial comparing 1vs 3-cm margins for melanoma 2 mm or thicker.
Setting: A multicenter trial was performed under the auspices of the United Kingdom Melanoma Study Group, the British Association of Plastic Surgeons, and the Scottish Cancer Therapy Network, coordinated by the Clinical Trials and Statistics Unit at the Institute of Cancer Research, Sutton, United Kingdom. Patients were recruited from January 1993 to July 2001.
Patients: Eligible . . . [Full Text of this Article] Comment
University of Michigan Medical School, Ann Arbor
H. Lee Moffitt Cancer Center and Research Institute, Tampa Fla
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Markers and Tissue Resources for Melanoma: Meeting Report.
Becker et al.
Cancer Res. 2006;66:10652-10657.
ABSTRACT
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