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The Predictive Value of Cutaneous Lesions of the Lumbosacral Region for Occult Spinal Dysraphism

Arch Dermatol. 2004;140:1153-1155.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The concept that specific cutaneous markers can be used to diagnose systemic diseases or malformations has always been of great interest to physicians. These associations are almost always noted by an astute clinician and then passed on by way of teaching, case reports, case series, review articles, and in textbooks. Modern medical science is advancing at an unprecedented pace; however, many of these clinically relevant hypotheses are never tested with traditional scientific methodology.

The observation that congenital anomalies of the skin and dysraphic conditions of the spinal cord coexist is more compelling than is the case with most cutaneous markers of systemic disease because the skin and the nervous system share an intimate embryologic origin. Immediately after the neural tube closes, the superficial ectoderm separates from the neuroectoderm in a process called disjunction. The superficial layers fuse in the midline to form continuous skin covering the neural tube. Incomplete or . . . [Full Text of this Article]

NOMENCLATURE


HIGH-RISK LESIONS

SENSITIVITY OF THE SCREENING EXAMINATION

SELECTION BIAS

STATISTICAL ANALYSIS
Beth A. Drolet, MD; Christian Boudreau, PhD

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