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When Good Is Not Good Enough
The Predictive Value of Cutaneous Lesions of the Lumbosacral Region for Occult Spinal Dysraphism
Arch Dermatol. 2004;140:1153-1155.
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The concept that specific cutaneous markers can be used to diagnose systemic diseases or malformations has always been of great interest to physicians. These associations are almost always noted by an astute clinician and then passed on by way of teaching, case reports, case series, review articles, and in textbooks. Modern medical science is advancing at an unprecedented pace; however, many of these clinically relevant hypotheses are never tested with traditional scientific methodology.
The observation that congenital anomalies of the skin and dysraphic conditions of the spinal cord coexist is more compelling than is the case with most cutaneous markers of systemic disease because the skin and the nervous system share an intimate embryologic origin. Immediately after the neural tube closes, the superficial ectoderm separates from the neuroectoderm in a process called disjunction. The superficial layers fuse in the midline to form continuous skin covering the neural tube. Incomplete or . . . [Full Text of this Article] NOMENCLATURE
HIGH-RISK LESIONS
SENSITIVITY OF THE SCREENING EXAMINATION
SELECTION BIAS
STATISTICAL ANALYSIS
Beth A. Drolet, MD;
Christian Boudreau, PhD
RELATED ARTICLE
Skin Markers of Occult Spinal Dysraphism in Children: A Review of 54 Cases
David Guggisberg, Smaïl Hadj-Rabia, Caroline Viney, Christine Bodemer, Francis Brunelle, Michel Zerah, Alain Pierre-Kahn, Yves de Prost, and Dominique Hamel-Teillac
Arch Dermatol. 2004;140(9):1109-1115.
ABSTRACT
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