This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Dermatology  • Dermatologic Disorders  • Diagnosis  • Dermatologic Disorders, Other  • Genetics  • Genetic Disorders  • Alert me on articles by topic  Social Bookmarking   What's this?

Arch Dermatol. 2004;140:1161-1166.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Multiple syringomas.

MICROSCOPIC FINDINGS

The skin biopsy specimen showed dermal fibrosis. In the upper dermis, there was a proliferation of eccrine-type ducts, many of which were dilated and contained eosinophilic material. The ducts were lined by 2 or more layers of cuboidal cells, often with luminal clear cell change. There was also a mild perivascular lymphohistiocytic inflammatory cell response. The epidermis displayed mild overlying hyperkeratosis.

DISCUSSION

Syringomas are benign tumors that originate in the intraepidermal eccrine ducts.¹ Clinically, they are asymptomatic, small, yellow or red-brown, firm papules. They are seen more frequently in females and commonly occur in the periorbital area, especially in patients with Down syndrome. Other sites that are affected less commonly include the neck, chest, and abdomen. The incidence of syringomas in patients with Down syndrome has been reported to be approximately 30 times greater than that in the general population.²

Friedman and Butler³ classified syringomas into the following 4 groups according . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Papular Eruption on a Patient With Down Syndrome—Quiz Case
Claire L. Martyn-Simmons and Lucy S. Ostlere
Arch Dermatol. 2004;140(9):1161-1166.
EXTRACT | FULL TEXT