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Arch Dermatol. 2004;140:1161-1166.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Axillary granular parakeratosis.

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Histologic examination of the punch biopsy specimen from an affected area showed a clearly thickened and compact stratum corneum above a typically differentiated and stratified epidermis. There was a clear retention of nuclei, with nuclear parakeratosis, in the corneocytes, and a number of intact keratohyaline granules were evident within the cytoplasm. These granules imparted basophilic properties to the compact horny layer. The epidermis was mildly acanthotic, with some hyperplasia of the rete ridges. In general, the keratinocytes appeared normal. A superficial perivascular lymphocytic inflammation was present in the dermis. No evidence of fungal infection was found on periodic acid–Schiff staining.

Based on the clinical and microscopic findings, a diagnosis of axillary granular parakeratosis was made. Topical 0.025% tretinoin therapy was initiated, with poor response. Oral isotretinoin therapy (40 mg/d) was then begun, and within 2 months, the skin eruption had completely cleared. The patient refused patch testing.

DISCUSSION

Granular parakeratosis is . . . [Full Text of this Article]

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Arch Dermatol. 2004;140(9):1161-1166.
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