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Nonhealing Verrucous Plaque on the Forearm—Diagnosis
Arch Dermatol. 2005;141:1457-1462.
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Diagnosis: Chromoblastomycosis.
MICROSCOPIC AND LABORATORY FINDINGS AND CLINICAL COURSE
The histopathologic findings included hyperkeratosis, pseudoepitheliomatous hyperplasia, and a granulomatous inflammatory reaction with microabscess formation. Spherical, brown sclerotic bodies were present in the inflammatory infiltrate (Figure 3). A silver stain confirmed the presence of fungal organisms. Tissue culture yielded Fonsecaea pedrosoi. Our patient is currently being treated with systemic terbinafine therapy combined with monthly cryotherapy. Some areas of regression have been noted.
Figure appears in full text version.
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DISCUSSION
Chromoblastomycosis is a subcutaneous mycosis that is acquired by cutaneous inoculation with dematiaceous fungi.1 Fonsecaea pedrosoi, Fonsecaea compactum, Cladosporium carrionii, Rhinocladiella aquaspersa, and Phialophora verrucosa are the 5 most commonly reported organisms causing chromoblastomycosis.2-3 Fonsecaea pedrosi is the most frequent isolate.4 These saprophytic fungi are found in decaying vegetation and soil and can cause human infection by transcutaneous implantation.1 Most lesions present on the lower extremities of persons working outdoors in agricultural occupations.2 Males are affected more often than . . . [Full Text of this Article]
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Nonhealing Verrucous Plaque on the Forearm—Quiz Case
Shanna B. Meads, Frances I. Ramos-Ceballos, and Francisco A. Ramos-Caro
Arch Dermatol. 2005;141(11):1457-1462.
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