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Intralesional immunotherapy employing skin test (recall) antigens derived from mumps, Candida, and Trichophyton is an effective and safe treatment for verruca vulgaris and verruca plana.^1-2 In adults, we have shown individual treated wart response rates of 60% to 74% (saline control, 22%) and complete clearing of uninjected anatomically distinct and distant warts in 49% to 71% (saline control, 16%). In children with treatment-resistant warts (2 modalities), complete response rates were 47% and 34%, respectively.³

Genital warts cause significant morbidity and discomfort. In addition to traditional destructive modalities, genital warts have been successfully treated by imiquimod, a biologic response modifier capable of increasing, among other cytokines, tissue levels of interferon-.⁴ Eradication of all baseline warts is reported in roughly 50% of subjects treated with 5% imiquimod cream. Differences in response rates between women (77%) and men (40%) have been reported.⁵ Intralesional injection of interferon alfa is also approved for the treatment . . . [Full Text of this Article]

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Mark King, MD; Sandra Marchese Johnson, MD; Thomas D. Horn, MD

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