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Erythematous Plaques With Fever and LeukocytosisDiagnosis
Arch Dermatol. 2005;141:263-268.
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Diagnosis: Sweet syndrome (SS).
MICROSCOPIC FINDINGS AND CLINICAL COURSE
The skin biopsy specimen revealed a dense inflammatory cell infiltrate throughout the papillary dermis that was composed of polymorphonuclear neutrophils and lymphocytes. There was no evidence of leukocytoclastic vasculitis, such as deposits of fibrinoid material around the capillaries, disruption of the vessel structure, or extravasation of erythrocytes. Oral prednisone therapy was initiated at a dosage of 1 mg/kg. Fifteen days later, only residual erythema was noted, and the fever and conjunctivitis had subsided.
DISCUSSION
Sweet syndrome, or acute febrile neutrophilic dermatosis, was described in 1964 by Robert Douglas Sweet.1 In 1986, Su and Liu2 proposed several criteria to serve as a guide for the diagnosis of SS. In 1994, von den Driesch3 revised the criteria, classifying them into 2 categories: major and minor. The major criteria consisted of (1) the abrupt onset of tender or painful erythematous plaques or nodules occasionally with vesicles, pustules, or bullae; and (2) a predominantly neutrophilic . . . [Full Text of this Article]
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Arch Dermatol. 2005;141(2):263-268.
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