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Multiple eruptive dermatofibromas (MDFs) are rarely encountered in clinical practice, as opposed to the common solitary dermatofibroma. They can develop suddenly in association with collagen vascular diseases, various autoimmune conditions, human immunodeficiency virus infection, or treatment with steroids. Association with acute myelogenous leukemia was reported in 1 case, and the immunosuppression was thought to be the cause of MDF.¹

Report of a Case

A 52-year-old man with chronic myelogenous leukemia was initially treated with interferon and imatinib. A hematologic relapse was controlled with escalating doses of busulfan, which reached 12 mg daily. However, pancytopenia occurred and busulfan treatment was discontinued. One month after becoming aplastic, the patient noticed the appearance of 3 dark, firm, nontender, slightly elevated nodules on his legs and arms. A skin biopsy revealed replacement of the dermis by stellate fibroblasts, some of which were multinucleated, and by randomly oriented collagen bundles. The overlying dermis was acantotic, and basal keratinocytes were . . . [Full Text of this Article]

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AUTHOR INFORMATION
Doru T. Alexandrescu, MD; Peter H. Wiernik, MD