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Infliximab for the Treatment of Adult-Onset Pityriasis Rubra Pilaris
Wennie C. Liao, MD;
Diya F. Mutasim, MD
From the Department of Dermatology, University of Cincinnati, Cincinnati, Ohio.
Arch Dermatol. 2005;141:423-425.
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REPORT OF CASES
CASE 1
A 77-year-old man presented in June 2002 with a 2-month history of a progressive eruption that initially involved his scalp and progressed to his face, neck, trunk, and extremities. This eruption was associated with chills. His medical history was remarkable for congestive heart failure, hypertension, a mitral valve repair, and gout. His medications included warfarin sodium, digoxin, losartan potassium, hydrochlorothiazide, and terazosin hydrochloride. He had also been taking prednisone and cephalexin prescribed by his primary care physician for his skin condition. Physical examination revealed erythematous, scaly plaques and papules on his scalp, face, neck, upper trunk, and proximal extremities (Figure 1). He had ectropion of both lower eyelids, keratoderma of the palms and soles, and significant pitting edema of the lower extremities. A biopsy specimen was obtained and revealed parakeratosis, moderate acanthosis, and a mild superficial perivascular lymphocytic infiltrate, consistent . . . [Full Text of this Article] CASE 2
THERAPEUTIC CHALLENGE
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