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Confluent Palatal and Gingival Papules in a 17-Year-Old Patient—Diagnosis
Arch Dermatol. 2005;141:515-520.
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Diagnosis: Verrucous nevus.
MICROSCOPIC FINDINGS
The palatal lesion consisted of multiple papillary projections of parakeratinized squamous epithelium supported by stalks of mildly inflamed vascular connective tissue (Figure 3). The gingival lesion showed epithelium with parakeratosis, acanthosis, and areas of pseudoepitheliomatous hyperplasia. The connective tissue was infiltrated by inflammatory cells, mainly lymphocytes, plasmacytes, and histiocytes. Koilocytes were absent (Figure 4). The results of investigations for detection of human papillomavirus DNA using in situ hibridization and polymerase chain reaction were negative.
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DISCUSSION
Epidermal nevi (EN) are organoid lesions that arise from the pluripotential germinative cells in the basal layer of embryonic epidermis. They are classified according to their predominant component as nevus verrucous (keratinocytes), nevus sebaceus (sebaceous glands), and nevus comedonicus (hair follicles).1 They are believed to result from somatic mutations of epidermal cells.2 The extent of the lesions is directly related to the period of development when such mutations . . . [Full Text of this Article]
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Arch Dermatol. 2005;141(4):515-520.
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